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CBD for Knee Pain

Written by: Lena Grammling

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Time to read 8 min

Whether due to injury, overuse, inflammation, or age-related wear and tear: knee pain can severely impact our daily lives. A promising alternative to traditional pain medications is CBD (Cannabidiol).


Numerous studies indicate an anti-inflammatory and pain-relieving effect of CBD against knee pain. The natural active ingredient is also a gentle therapy option with no addictive potential.


Here you will learn about the causes, symptoms, and treatment options for knee pain, and how CBD can help you with joint pain.

Knee Pain: Causes, Symptoms, and Treatment Options

The miraculous knee - The largest joint in the human body is a complex system of bones, cartilage, ligaments, menisci, tendons, and muscles.


In a healthy state, it is flexibly bendable and extendable, as well as minimally rotatable, allowing us countless movements from climbing stairs and running to cycling. Therefore, it's no wonder that nothing can reduce our well-being as quickly as knee pain.

Causes

Not least because of its special construction, the knee joint is susceptible to injuries and wear and tear of all kinds. Malalignments, damage from intensive sports (ligament, meniscus injuries), relevant strains, as well as inflammatory diseases and age-related changes (cartilage changes, joint degeneration) are the main causes of knee pain.


Due to its complexity, diagnosing the cause of knee problems is often a challenge. In addition to a physical examination, imaging techniques (stress X-rays, MRI) are usually necessary for accurate clarification to avoid premature, unnecessary operations.


Knee pain can have various causes depending on its location:


  • Anterior knee pain (anterior knee joint, anterior upper or lower leg) often radiates from the kneecap (patella). Reasons for this can be dislocations, subluxations, patellar malformations, bursitis, patellar tendinopathy (overuse of the patellar tendon), or retropatellar arthrosis (permanent joint wear behind the kneecap).

  • Medial knee pain often occurs with medial collateral ligament or medial meniscus injuries, arthrosis, inflamed bursae, and tendon damage (e.g., to the hamstrings).

  • Lateral knee pain can indicate lateral collateral ligament or lateral meniscus injuries, knee misalignments, arthrosis of the lateral knee joint space, irritated and worn tendons (especially in endurance athletes), and the so-called "runner's knee."

  • Popliteal pain often originates from the joint capsule and can be due to knee osteoarthritis, damage to the posterior cruciate ligament, or a Baker's cyst.

*Good to know
In chronic inflammatory diseases such as rheumatoid arthritis, usually the entire knee joint is affected by painful changes (redness, swelling, damage to ligaments up to joint destruction).

Symptoms

Knee pain has various manifestations. Acute knee pain occurs suddenly, lasts only a few hours to a few days, and usually subsides spontaneously. If the pain persists for at least six weeks, it is referred to as chronic knee pain. At this point, at the latest, an orthopedic assessment should be sought to prevent secondary or permanent damage.


The most common symptoms of knee pain include:


  • Pain with movement or weight-bearing

  • Resting pain

  • Feeling of stiffness (with start-up pain)

  • Restricted mobility / decreasing stability

  • Grinding / rubbing noises (when straightening the knee or squatting)

  • Swelling

  • Bruising

  • Redness of the surrounding skin

  • Overheating or fever

If these symptoms apply to you, you should consult an orthopedic practice. Especially if you are older than 25, an active athlete, or exposed to physical stress at work.

Treatment Options

Depending on the cause of your knee pain, various treatment options are available. Acute pain is usually treated with local or systemic painkillers. These measures also contribute to pain relief:


  • Rest, immobilization

  • Cold/heat applications

  • Strengthening exercises

  • Physiotherapy

  • Ultrasound, electrostimulation therapy

  • Bandages, insoles, gel supports

  • Treatment of the underlying disease (arthrosis, rheumatism)

*Good to know
Operations are always a last resort. Around three-quarters of all knee operations performed are unnecessary, which is why accurate diagnosis in the knee area is all the more important.

Woman with knee pain

How does CBD help with knee pain?

The therapies for knee pain are diverse, depending on the cause. Common medications often come with undesirable side effects. The therapeutic potential of CBD has been known for some time.


CBD exerts its effects in our body through the endocannabinoid system (ECS), which interacts closely with the nervous system. By binding to specific receptors, CBD intervenes in numerous physiological processes relevant to pain and inflammation.


CBD works on several levels:

Immunomodulatory / anti-inflammatory:

By modulating the immune response, CBD reduces the overactivity of the immune system and can thus reduce inflammatory processes in the knee joint.

Pain-relieving:

By docking to specific receptors such as CB1 and CB2, CBD acts as a pain reliever and anti-inflammatory.¹ ²

Positive effect on pain memory:

Pain memory, activated by prolonged pain, reacts to the smallest discomforts with a strong pain response. CBD can interrupt this cycle.

Sleep-promoting:

Restful sleep is essential for normal pain perception and wound healing.³ CBD can have a deeply relaxing and sleep-promoting effect.

CBD for knee pain: The study situation

Numerous scientific studies indicate a positive effect of CBD on joint pain.


A meta-analysis from 2017 suggested that cannabis could be a potential treatment option for joint pain.⁴


In a cell culture study (2020), CBD showed an anti-arthritic and anti-inflammatory effect on synovial fibroblasts.⁵


A review (2021) of preclinical data indicated a potential analgesic and anti-inflammatory effect of CBD.⁶


Topical cannabidiol treatment in a clinical study (2022) resulted in significant symptom improvements (pain, limited mobility) in patients with thumb basal joint arthritis.⁷


In another study (2022), CBD intake (25–75 mg/day) led to a reduction in arthritis symptoms and necessary medication.⁸


A systematic literature review (2023) showed that CBD supplementation can be a promising therapeutic adjunct for pain reduction and improved quality of life in rheumatism patients.⁹

Application of CBD for knee pain and joint problems

Various dosage forms are available for the application of CBD for joint pain.

External Application

CBD oils and balms are particularly popular for external use. Since the bioavailability of topically applied oils is rather low and side effects are rare, higher-dose products such as full-spectrum CBD oil 25% or full-spectrum CBD oil 30% can also be chosen.


Application: CBD oils and balms can be applied to the desired area once or twice daily. Please avoid open wounds!

Internal Application

Want more? If the effect of CBD is to go beyond local symptom relief, an oral preparation can be beneficial. Orally ingested CBD oil quickly enters the bloodstream and takes effect throughout the body – including the knee. If you are new to CBD, a product with a lower CBD dose is advisable at first, such as the full-spectrum CBD oil 10%. Later, and if well tolerated, you can then switch to higher-dosed preparations.


Application: Place a few drops of the CBD oil of your choice under the tongue one to three times a day and hold it there for about 60 seconds. This ensures optimal absorption. The dosage can be gradually increased or adjusted.

*Tip
For post-sport recovery, we recommend our CBD Sport Oil 10%. Thanks to its special formula, it has antispasmodic, anti-inflammatory, and relaxing effects.

*Tip
For even more restful nights and better regeneration, use our CBD sleep oil with melatonin and chamomile.

*Combined application
To achieve a stronger effect, you can use CBD products both externally and internally. This holistic approach will help you regain your quality of life even faster.

Our customers' opinions:

"I am a 42-year-old athlete who struggles with mild arthritis and medial collateral ligament issues in my knee, as well as elevated blood pressure. By taking 3x 3 drops of CBD oil (5%) daily, I am now pain-free! The inflammation has definitely subsided, and athletic exertion no longer causes any problems."

A. Schramm, July 26, 2021

"Excellent service and excellent products, my knee is already much better after daily treatment with CBD oil!"

Walter S., May 13, 2021

Further tips for dealing with knee pain

In addition to using CBD for knee pain, the following measures can also be helpful:


  • Weight reduction: Excessive body weight can permanently damage the sensitive knee joint. Nutritional counseling can help you lose excess pounds.

  • Regular exercise: Regular physical activity keeps you fit and strengthens tendons, ligaments, and muscles. This stabilizes the joints and relieves the cartilage.

  • Psychological support: Especially with persistent pain, tips for mental pain management are often helpful.

Conclusion

Thanks to its anti-inflammatory, immune-regulating, and pain-relieving properties, CBD can alleviate joint pain. CBD products can be used topically, orally, or in combination and are a gentle, non-psychoactive treatment option. Although the use of CBD for knee pain cannot replace a medically prescribed (pain) therapy, it can certainly be a supportive measure for greater well-being.

Sources and Studies

1. M. Schrimpf, G. Liegl, M. Boeckle, A. Leitner, P. Geisler, C. Pieh: The effect of sleep deprivation on pain perception in healthy subjects: a meta-analysis. In: Sleep Medicine. Volume 16, Issue 11, 2015, pp. 1313–1320, ISSN 1389-9457. https://doi.org/10.1016/j.sleep.2015.07.022


2. N. Clayton, F.H. Marshall, C. Bountra, C.T. O'Shaughnessy: CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain. In: Pain. Volume 96, Issue 3, 2002, pp. 253–260, ISSN 0304-3959. https://doi.org/10.1016/S0304-3959(01)00454-7.


3. R. Likar, M. Köstenberger, G. Nahler: Cannabidiol bei Tumorerkrankungen. In: Schmerz. Volume 34, 2020, pp. 117–122. https://doi.org/10.1007/s00482-019-00438-9.


4. R.J. Miller, R.E. Miller: Is cannabis an effective treatment for joint pain? In: Clinical and Experimental Rheumatology. Volume 35 Suppl 107(5), 2017, pp. 59–67. PMID: 28967368.


5. T. Lowin, R. Tingting, J. Zurmahr, T. Classen, M. Schneider, G. Pongratz: Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts. In: Cell Death and Disease. Volume 11, Issue 8, 2020, p. 714. doi: 10.1038/s41419-020-02892-1. PMID: 32873774; PMCID: PMC7463000.


6. D.P. Finn, S. Haroutounian, A.G. Hohmann, E. Krane, N. Soliman, A.S.C. Rice: Cannabinoids, the endocannabinoid system, and pain: a review of preclinical studies. In: Pain. Volume 162 Suppl 1, 2021, pp. S5–S25. doi:10.1097/j.pain.0000000000002268. PMID: 33729211; PMCID: PMC8819673.


7. J.T. Heineman, G.L. Forster, K.L. Stephens, P.S. Cottler, M.P. Timko, B.R. DeGeorge Jr.: A Randomized Controlled Trial of Topical Cannabidiol for the Treatment of Thumb Basal Joint Arthritis. In: Journal of Hand Surgery American. Volume 47, Issue 7, 2022, pp. 611–620. doi: 10.1016/j.jhsa.2022.03.002. PMID: 35637038.


8. N. Frane, E. Stapleton, C. Iturriaga, M. Ganz, V. Rasquinha, R. Duarte: Cannabidiol as a treatment for arthritis and joint pain: an exploratory cross-sectional study. In: Journal of Cannabis Research. Volume 4, Number 1, 2022, p. 47. doi: 10.1186/s42238-022-00154-9. PMID: 35999581; PMCID: PMC9400326.


9. P. Hoermann: The effects of cannabidiol (CBD) supplementation on inflammatory-rheumatic diseases in adults with a special focus on rheumatoid arthritis. Systematic literature search. HAW Hamburg, 2023. Available at: https://reposit.haw-hamburg.de/bitstream/20.500.12738/14805/1/BA_Cannnabidiol.pdf.