CBD Effects - How Does Cannabidiol Affect the Body?
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Time to read 8 min
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Time to read 8 min
CBD (Cannabidiol) is increasingly coming into focus for people seeking natural ways to manage physical complaints such as pain, anxiety, sleep disorders, and inflammation. The specific effects of CBD offer an ideal solution for those who want to enhance their well-being without the psychoactive side effects of classic cannabis products.
Despite CBD's impressive potential and its diverse effects, many find it difficult to find reliable and detailed information about its benefits. As CBD experts, we aim to provide detailed insights into how CBD works, its possible applications, and its multifaceted effects in this article.
CBD has a calming effect on the nervous system, alleviates pain and inflammation, and can help with anxiety and sleep problems by supporting the body's endocannabinoid system.
CBD has a calming and relaxing effect: It can reduce stress, improve sleep quality, and help with discomforts such as mild pain and inflammation without causing psychoactive effects.
The effect and duration of action vary depending on the form of intake: CBD oil usually acts within 15–30 minutes, while capsules take longer as they are absorbed through the digestive tract.
CBD is considered safe and well-tolerated: It has no addictive potential and no intoxicating effect, but in rare cases, it can cause mild side effects such as fatigue or dry mouth.
CBD stands for Cannabidiol, an active ingredient extracted from the cannabis plant. Unlike THC (Tetrahydrocannabinol), another component of the hemp plant, CBD's effect is not intoxicating and therefore does not cause a "high."
The fact that CBD does not produce psychoactive effects makes it particularly attractive for those who want to experience therapeutic benefits without an altered state of consciousness.
To understand how CBD works, one must become familiar with the Endocannabinoid System (ECS). This system is found in the brain and nervous systems of all mammals and enables the interaction between CBD and the organism. CBD and THC, both cannabinoids, can attach to various cannabinoid receptors within the ECS, thereby modulating different functions in the body.
Within this system, CBD primarily interacts with two types of cannabinoid receptors: CB1, predominantly found in the brain and central nervous system, and CB2, primarily located in the peripheral nervous system and immune system. While THC shows a strong binding affinity to CB1 receptors, leading to its psychoactive effects, CBD exhibits a lower direct binding capacity to these cannabinoid receptors. Instead, CBD influences the ECS indirectly by modulating the activity of other cannabinoids and endogenous endocannabinoids, which can contribute to its therapeutic effects.
The ECS functions as a sophisticated communication network between the body and the brain, regulating essential bodily functions and processes such as pain perception, mood, appetite, sleep, and immune response.¹
Through interaction with the ECS, CBD offers a range of health benefits. CBD acts like a conductor, harmonizing the orchestra of the body's cells and systems, thereby contributing to the maintenance and restoration of bodily balance, also known as homeostasis.²
CBD is highly valued for its calming properties and its ability to create a balance between body and mind. It interacts with the body's own Endocannabinoid System (ECS), thereby promoting the body's natural equilibrium, known as homeostasis.
CBD helps regulate the body's functions, especially during stressful times, and thus improves overall well-being. The beneficial influence of CBD on the ECS opens up new perspectives in health promotion. A growing number of scientific studies confirm the therapeutic potential of CBD.
The applications of CBD are diverse and extend across several aspects of physical and mental health. Here are some of the most common areas of application:
The positive effect of CBD therapies on various areas has already been demonstrated in several controlled studies. However, more extensive human studies are still needed to gain deeper insights and make more precise statements.
CBD products offer diverse applications and effects, suited to different needs:
CBD oils and tinctures
CBD Capsules
CBD Edibles
CBD Vape Products
CBD is generally considered safe and well-tolerated.
"CBD generally has a good safety profile and is well tolerated," according to the World Health Organization WHO⁸
Nevertheless, side effects such as dry mouth, fatigue, dizziness, and gastrointestinal discomfort may occur. These vary individually and usually subside as the effect wears off.
We recommend the following measures to minimize the risk of side effects:
By following these guidelines, you can minimize the risk of side effects while maximizing the benefits of CBD.
CBD has established itself as a versatile, plant-based active ingredient that contributes to supporting physical and mental well-being. Given its broad spectrum of applications, health benefits, and effectiveness, there is great interest in the role of CBD in health promotion, which is leading to an increase in scientific studies in this area. To optimally utilize the effects of CBD, it is advisable to adapt its use individually and in consultation with experts to achieve targeted results for one's own well-being.
The speed of CBD's effect heavily depends on the form of intake. CBD oil, dropped under the tongue, can take effect in as little as 15–30 minutes. Capsules and edible products often take longer as they are absorbed through the digestive tract, which can take up to an hour.
The effects of CBD generally last between 2 and 6 hours. The duration of CBD's effect depends on factors such as dosage, form of intake, and individual physical conditions.
There is no universal dosage for CBD, as the optimal amount varies individually. Beginners often start with a low dose (5–10 mg) and gradually increase it until the desired effect is achieved. The dosage should always be adjusted to personal needs and the desired goal.
No, the effects of CBD can vary from person to person. Factors such as age, metabolism, body weight, and the presence of specific receptors influence how CBD works in the body.
Sources and Studies
¹ Sallaberry, C. & Astern, L. (2018). The Endocannabinoid System, our universal regulator. Journal of Young Investigators. 34 (6), pp. 48-55. Downloaded on January 26, 2024, from [Source]
² Patel, R. (2019). Healthy with CBD Oil. The miracle cure for stress, pain, sleep disorders and more. Dorling Kindersley Verlag: Munich.
³ Henson, J.D., Vitetta, L., Quezada, M., Hall, S. (2021). Enhancing Endocannabinoid Control of Stress with Cannabidiol. Journal of Clinical Medicine. 10 (24), 5852. doi: 10.3390/jcm10245852. PMID: 34945148; PMCID: PMC8704602. Downloaded on March 23, 2023, from [Source]
⁴ Shannon, S., Lewis, N., Lee, H., Hughes, S. (2019). Cannabidiol in Anxiety and Sleep: A Large Case Series. The Permanente Journal. 23, 18-041. doi: 10.7812/TPP/18-041. Downloaded on March 23, 2023, from [Source]
⁵ Moeller-Bertram, T., Schilling, J., Hughes, C., Wallace, M., Sexton, M., Backonja, M. (2019). (360) Can CBD Reduce the Use of Pain Medication? Lessons from a Survey in a Pain Clinic Environment. The Journal of Pain. 20 (4), Supplement, S64. Downloaded on March 23, 2023, from [Source]
⁶ Tóth, K.F., Ádám, D., Bíró, T., Oláh, A. (2019). Cannabinoid Signaling in the Skin: Therapeutic Potential of the "C(ut)annabinoid" System. Molecules. 24 (5), 918. doi: 10.3390/molecules24050918. PMID: 30845666; PMCID: PMC6429381. Downloaded on March 23, 2023, from [Source]
⁷ Jadoon, K.A., Tan, G.D., O’Sullivan, S.E. (2017). A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study. JCI Insight. 2 (12), e93760. Downloaded on February 2, 2024, from [Source]
⁸ WHO. (2024). Cannabidiol (CBD). Critical Review Report. Downloaded on January 23, 2024, from [Source]
⁹ Xiong, W., Cui, T., Cheng, K., Yang, F., Chen, S.R., Willenbring, D., Guan, Y., Pan, H.L., Ren, K., Xu, Y., & Zhang, L. (2012). Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. The Journal of Experimental Medicine. 209 (6), pp. 1121–1134 from [Source]
